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Americas Top 1,000 Companies List by Market Cap as of August 2026

Americas Top 1,000 Companies List by Market Cap as of August 2026, Americas Biggest 1,000 Companies by Market Cap, Americas Largest 1,000 Companies List as of August 2026.

Metatag Title
Americas Largest and Top 1,000 Companies in 2026
Metatag Abstract
Americas Top 1,000 Companies by Market Cap in 2026, Americas 1,000 Biggest Companies by Market Cap in 2026, Americas 1,000 Largest Companies in 2026.
  1. Rank in Search Criteria: 2021
    World Rank (Aug-2026): 5,432
    Market Cap (Aug-2026): 2.634 Billion USD
    World Rank (Jan-05-2024): 9,334
    Market Cap (Jan-05-2024): 0.87 Billion USD
    World Rank (Jul-30-2023): 9662
    Market Cap (Jul-30-2023): 0.84 Billion USD
    World Rank (Jan-2022): 9,868
    Market Cap (Jan-2022): 0.92 Billion USD
    Headquarters Country: USA
    Annual Revenue in USD: 592 Million USD
    Annual Operating Income in USD: -124 Million USD
    Annual Net Income in USD: -39 Million USD
    Annual Results for Period ending: Dec-2022 ending year
    Employee Count: 700
    Employee Count as of Date: As on 2022
    Company Profile:

    Rush Street Interactive is a developing, supplying and operating regulated Online Gaming company. The headquarters is in USA.

    Facts About Company:

    Rush Street Interactive Annual Total Revenue for year ending Dec-2022 was 592 million USD and and Net loss for year ending Dec-2022 was -38 million USD.

    Rush Street Interactive Annual Total Revenue for year ending Dec-2021 was 488 million USD and and Net loss for year ending Dec-2021 was -19 million USD.

    As on 2022, Rush Street Interactive has 700 employees.

  2. Rank in Search Criteria: 2022
    World Rank (Aug-2026): 5,432
    World Rank (Jan-05-2024): 5,432
    World Rank (Jul-30-2023): 5432
    World Rank (Jan-2022): 5,432
    Headquarters Country: USA
    Company Profile:

    Portola Pharmaceuticals is a Biotechnology company. It is having more than 380 employees and has offices around the globe and serves patients in more than 50 countries. The company has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome (aHUS) as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder. The headquarters is in USA.

    Alexion acquired Portola Pharmaceuticals for 1.41 billion USD.

  3. Rank in Search Criteria: 2023
    World Rank (Aug-2026): 5,434
    Market Cap (Aug-2026): 2.633 Billion USD
    World Rank (Jan-05-2024): 6,023
    Market Cap (Jan-05-2024): 1.82 Billion USD
    World Rank (Jul-30-2023): 5782
    Market Cap (Jul-30-2023): 1.98 Billion USD
    World Rank (Jan-2022): 9,999
    Market Cap (Jan-2022): 0.90 Billion USD
    Headquarters Country: USA
    Business Sector:
    Annual Revenue in USD: 1,651 Million USD
    Annual Operating Income in USD: 736 Million USD
    Annual Net Income in USD: 381 Million USD
    Annual Results for Period ending: Dec-2022 ending year
    Employee Count: 443
    Employee Count as of Date: As on 2021
    Company Profile:
    Talos Energy is a Offshore Energy company. It is focused on oil and gas exploration, production and operations across a range of deepwater and shallow water assets in the United States Gulf of Mexico and offshore Mexico. The headquarters is in USA.
    Stock Price: Yahoo @ NYSE
    Company Website: TALOS ENERGY INC
  4. Rank in Search Criteria: 2024
    World Rank (Aug-2026): 5,440
    Market Cap (Aug-2026): 2.630 Billion USD
    World Rank (Jan-05-2024): 22,095
    Market Cap (Jan-05-2024): 0.09 Billion USD
    World Rank (Jul-30-2023): 20000
    Market Cap (Jul-30-2023): 0.14 Billion USD
    World Rank (Jan-2022): 21,111
    Headquarters Country: USA
    Business Sector:
    Company Profile:

    Trevi Therapeutics is a clinical-stage biopharmaceutical company that is developing the investigational therapy Haduvio™ to treat serious chronic cough conditions by targeting the central and peripheral nervous systems. Headquarters is in USA.

    Stock Price: Yahoo @ Nasdaq
    Company Website: TREVI THERAPEUTICS
  5. Rank in Search Criteria: 2025
    World Rank (Aug-2026): 5,454
    Market Cap (Aug-2026): 2.622 Billion USD
    World Rank (Jan-05-2024): 6,231
    Market Cap (Jan-05-2024): 1.72 Billion USD
    World Rank (Jul-30-2023): 6500
    Market Cap (Jul-30-2023): 1.64 Billion USD
    Headquarters Country: USA
    Stock Price: Yahoo @ NYSE
  6. Rank in Search Criteria: 2026
    World Rank (Aug-2026): 5,456
    Market Cap (Aug-2026): 2.620 Billion USD
    World Rank (Jan-05-2024): 15,954
    Market Cap (Jan-05-2024): 0.29 Billion USD
    World Rank (Jul-30-2023): 14713
    Market Cap (Jul-30-2023): 0.37 Billion USD
    World Rank (Jan-2022): 14,686
    Market Cap (Jan-2022): 0.41 Billion USD
    Headquarters Country: USA
    Annual Revenue in USD: 112 Million USD
    Annual Net Income in USD: -24 Million USD
    Annual Results for Period ending: Dec-2020 ending year
    Company Profile:
    Axogen is a company focused specifically on the science, development and commercialization of technologies for peripheral nerve regeneration and repair. The headquarters is in USA.
    Facts About Company:
    Axogen company annual revenue was 138 million USD and annual net loss was -28 million USD as on Dec-2022.
    Stock Price: Yahoo @ Nasdaq
    Company Website: AXOGEN
  7. Rank in Search Criteria: 2027
    World Rank (Aug-2026): 5,458
    World Rank (Jan-05-2024): 5,458
    World Rank (Jul-30-2023): 5458
    World Rank (Jan-2022): 5,458
    Market Cap (Jan-2022): 2.52 Billion USD
    Headquarters Country: USA
    Annual Revenue in USD: 0 Million USD
    Annual Net Income in USD: 0 Million USD
    Annual Results for Period ending: Dec-2021 ending year
    Company Profile:
    First Midwest Bancorp is a Retail Banking Holding company. It is the 3rd largest independent Illinois headquartered bank, total assets is $20B, assets under management is $11B, total deposits is $15.7B. The company is having more than 100 locations and dedicated consumer, small business, mortgage and ecommerce teams and having more than 55,000 free ATMS, world class mobile banking and four checking account choices to meet needs. The headquarters is in USA.
    Company Website: FIRST MIDWEST BANCORP INC
  8. Rank in Search Criteria: 2028
    World Rank (Aug-2026): 5,459
    World Rank (Jan-05-2024): 5,459
    World Rank (Jul-30-2023): 5459
    World Rank (Jan-2022): 5,459
    Headquarters Country: Canada
    Employee Count: 620
    Employee Count as of Date: As on 2019
    Company Profile:
    Aphria is a Canadian Cannabis company. It has a market capitalization of $1.2 billion as of January 2020. The headquarters is in Canada.
    Company Website: APHRIA
  9. Rank in Search Criteria: 2029
    World Rank (Aug-2026): 5,463
    Market Cap (Aug-2026): 2.614 Billion USD
    World Rank (Jan-05-2024): 5,555
    Market Cap (Jan-05-2024): 2.07 Billion USD
    World Rank (Jul-30-2023): 5345
    Market Cap (Jul-30-2023): 2.24 Billion USD
    World Rank (Jan-2022): 5,280
    Market Cap (Jan-2022): 2.66 Billion USD
    Headquarters Country: USA
    Annual Revenue in USD: -192 Million USD
    Annual Operating Income in USD: -196 Million USD
    Annual Net Income in USD: -196 Million USD
    Annual Results for Period ending: Dec-2022 ending year
    Employee Count: 354
    Employee Count as of Date: As on December 2021
    Company Profile:

    COHEN & STEERS INFRASTRUCTURE FUND is a closed-end equity fund launched by Cohen & Steers, Inc. The fund is managed by Cohen & Steers Capital Management, Inc. It invests in public equity markets of the United States. The fund invests primarily in value stocks of infrastructure companies across all market capitalizations.

    It was formerly known as Cohen & Steers Select Utility Fund, Inc. Cohen & Steers Infrastructure Fund, Inc. was formed on January 8, 2004 and Headquarters is in USA.

    Stock Price: Yahoo @ NYSE
  10. Rank in Search Criteria: 2030
    World Rank (Aug-2026): 5,466
    Market Cap (Aug-2026): 2.612 Billion USD
    World Rank (Jan-05-2024): 3,549
    Market Cap (Jan-05-2024): 3.94 Billion USD
    World Rank (Jul-30-2023): 4303
    Market Cap (Jul-30-2023): 3.05 Billion USD
    World Rank (Jan-2022): 3,267
    Market Cap (Jan-2022): 5.03 Billion USD
    Headquarters Country: USA
    Annual Revenue in USD: 363 Million USD
    Annual Operating Income in USD: -648 Million USD
    Annual Net Income in USD: -707 Million USD
    Annual Results for Period ending: Dec-2022 ending year
    Employee Count: 1,119
    Employee Count as of Date: As on 2021
    Company Profile:

    Ultragenyx Pharmaceutical is a Clinical Stage Biopharmaceutical company. It committed to bringing to patients novel products for the treatment of rare and ultra rare diseases with a focus on serious debilitating genetic diseases. The company portfolio of approved therapies and product candidates aimed at addressing diseases with high unmet medical need and clear biology for which there are no approved therapies. The headquarters is in USA.

    Stock Price: Yahoo @ Nasdaq

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